Dose #5 of methotrexate for my RA this weekend; seems it makes me sick for 2.5 days, and the rest of the week is better, joint-pain wise, but it's definitely no magic bullet yet. At least there is some improvement even after a month; doc said 6-8 weeks to get a good view of its effectiveness. Nausea and GI issues are getting a bit better as well. Will see the rheumatologist next week to find out if my liver is doing well enough to continue this therapy, or I have to chuck it and try another biologic.
At least I don't have to deal with that damn herniated disc now! Back is doing well. Walking is fine, though I'm slow and still limp at times because of the RA f'ing up my left hip and knees faster than I'd hoped. Still looking forward to the Brooklyn Bridge walk in July. It will be slow going, but I know I can do it.
Still avoiding lifting more than 10 lbs through the 9 month recovery from the L5-S1 bilateral discectomy in January. Otherwise no problems bending or twisting. The surgery was sanity-saving/life-altering, Laurel. I had no idea how much the back pain was affecting my ability to cope (from any perspective). I could easily see how people might be afraid of spinal surgery, but for me, there was no alternative. I couldn't cope with sciatica pain plus the RA. I was starting to lose it re: pain tolerance. Mine's pretty high, but I hit the wall on this one.
Back surgery gone wrong is a nightmare -- my particular surgery has a high "success" rate (~95%), but the definition of success is quite specific -- relief of the acute pain. There's no guarantee that nerve damage that causes numbness will go away, but that's livable. Some people have full recovery from that as well, but that's months down the road before you can know. I already had unrelated permanent nerve damage/neuropathy in my feet, so my expectations in that area were realistic -- as in no chance that was going away. So from my POV the surgery did what was accomplished with no serious complications.
As I mentioned, the remaining issues affecting walking (speed, mostly), for instance, are related to RA, and that's progressive/degenerative. Just have to do my best to slow it down.
Methotrexate is used to treat severe psoriasis (a skin disease in which red, scaly patches form on some areas of the body) that cannot be controlled by other treatments. Methotrexate is also used along with rest, physical therapy and sometimes other medications to treat severe active rheumatoid arthritis (RA; a condition in which the body attacks its own joints, causing pain, swelling, and loss of function) that cannot be controlled by certain other medications. Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia (cancer that begins in the white blood cells). Methotrexate is in a class of medications called antimetabolites. Methotrexate treats cancer by slowing the growth of cancer cells. Methotrexate treats psoriasis by slowing the growth of skin cells to stop scales from forming. Methotrexate may treat rheumatoid arthritis by decreasing the activity of the immune system.